^{1. Hexal AG. ACC long 600 mg (effervescent tablets). Patient information. February 2020.}

^{2. Hexal AG. ACC 200 mg (powder for oral solution). Patient information. January 2020.}

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PRESENTATION: ACC^® 200 mg: One Sachet with 3 g powder contains 200 mg acetylcysteine.
ACC^® long: One effervescent tablet contains 600 mg acetylcysteine. INDICATION: ACC 200 & ACC long: contains the active substance acetylcysteine and liquefies viscous mucus in the airways. ACC 200 mg powder for oral solution is used to loosen mucus and to ease coughing up in cases of respiratory diseases with viscous mucus in children from 6 years, adolescents and adults. ACC long is used to loosen mucus and to ease coughing up in cases of cold – induced bronchitis in adolescents over 14 years of age and adults. DOSAGE: ACC 200: Children and adolescents from 6-13 years: 1 sachet 2 times daily. Adults and adolescents aged 14 years and older: 1 sachet 2-3 times daily. Treatment of mucoviscidosis in children aged over 6 years: 1 sachet 3 times daily. ACC long: For adults and adolescents over the age of 14 year, ½ effervescent tablet twice daily or 1 effervescent tablet once daily .OVERDOSING: ACC 200 & ACC long : Irritations in the stomach and bowel tract may occur, such as abdominal pain, nausea, vomiting, diarrhoea. if an overdose is suspected, please inform your doctor CONTRAINDICATIONS: ACC 200 & ACC long :allergic to acetylcysteine, , or any of the ingredients of this medicine. ACC 200: children under 2 years of age, children under 6 years of age. ACC long: children and adolescent under 14 years. PRECAUTIONS/WARNINGS: ACC 200& ACC long: Caution is advised if you have bronchial asthma and a history of stomach or bowel ulcers or currently have them, patients with hypersensitivity to histamine. An inability to cough up mucous. If skin and mucosal changes newly occur, medical advice should be sought without delay and use of acetylcysteine be terminated. INTERACTIONS: ACC 200 & ACC long: Antibiotics ,tetracyclines, aminoglycosides, penicillins, Cough-relieving agents, , Activated charcoal ,Nitroglycerin. ACC long: carbamazepine. Pregnancy and lactation: ACC 200 & ACC long: you should use ACC long during pregnancy and lactation only if your attending physician considers this absolutely necessary. Take ACC 200 or ACC long after meals. ACC 200 & ACC long is not known to influence the ability to drive or operate machines. SIDE EFFECTS: ACC Long: Two serious side effects are the severe skin reactions such as Stevens-Johnson syndrome (painful red or purplish rash that spreads and blisters) and / or Lyell Syndrome (mucosal lesions only or both mucosal and skin lesions including bubble formations). They have been reported in temporal association with the use of acetylcysteine. In most of these reported cases, at least one additional drug that could potentially have intensified the described mucocutaneous effects was being taken at the same time. If skin or mucous membrane abnormalities develop, medical advice should therefore immediately be sought and the use of acetylcysteine discontinued. PHARMACEUTICAL PRECAUTIONS: ACC 200 & ACC Long: Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the sachet and the carton after EXP.The expiry date refers to the last day of that month. ACC 200: Store Below 25°C, in a dry place, ACC long: Do not store above 25°C.keep the tube tightly closed in order to protect from moisture .NOTE: Before prescribing, please read full prescribing information. REFERENCE: ACC 200: Approved PIL, revision date January 2020. ACC long: Approved PIL, revision date February 2020. BSS DATE: June 2021